CABAS: a freely available PC program for fitting calibration curves in chromosome aberration dosimetry

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01/04/2007

Titre de la revue : Radiation Protection Dosimetry Volume : 124 N° : 2 Pagination : 115-123 Date de publication : 01/04/2007

Type de document > *Article de revue
Unité de recherche > IRSN/DRPH/SRBE/LDB
Auteurs > DEPERAS Joanna , DEPERAS-KAMINSKA Marta , EDWARDS A. , LINDHOLM Carita , LLOYD David , MORAND Josselin , MOSS Raymond , ROMM Horst , ROY Laurence , SZUISKA Marta , WOJCIK Andrzej

The aim of biological dosimetry is to estimate the dose and the associated uncertainty to which an accident victim was exposed. This process requires the use of the maximum-likelihood method for fitting a calibration curve, a procedure that is not implemented in most statistical computer programs. Several laboratories have produced their own programs, but these are frequently not user-friendly and not available to outside users. We developed a software for fitting a linear-quadratic dose-response relationship by the method of maximum-likelihood and for estimating a dose from the number of aberrations observed. The program called as CABAS consists of the main curve-fitting and dose estimating module and modules for calculating the dose in cases of partial body exposure, for estimating the minimum number of cells necessary to detect a given dose of radiation and for calculating the dose in the case of a protracted exposure.

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